实用医学杂志 ›› 2022, Vol. 38 ›› Issue (21): 2755-2758.doi: 10.3969/j.issn.1006⁃5725.2022.21.022

• 综述 • 上一篇    下一篇

载阿霉素脂质体在胶质瘤治疗中的应用

王梦欣1,2罗岚1 姚荣权1 林淑萍1 陈芸1   

  1. 1 北京大学深圳医院超声科(广东深圳 518000);2 北京大学医学部(北京 100089)

  • 出版日期:2022-11-10 发布日期:2022-11-10
  • 通讯作者: 陈芸 E⁃mail:chenyun6308@139.com
  • 基金资助:

    中国国家自然科学基金资助项目(编号:81901767); 广东省自然科学基金资助项目(编号:2022A1515010986);广东省 高水平医院建设专项经费资助基金资助项目(编号:粤办函 2019]260 号);深圳市医学重点学科建设经费资助项目(编号: SZXK051

Application of doxorubicin⁃loaded liposomes in the treatment of glioma

WANG Mengxin*,LUO Lan,YAO Rongquan,LIN Shuping,CHEN Yun.   

  1. Department of Ultrasound,Peking University Shenzhen Hospital,Shenzhen 518000,China;*Peking University Health Science Center,Beijing 100089,China

  • Online:2022-11-10 Published:2022-11-10
  • Contact: CHEN Yun E⁃mail:chenyun6308@139.com

摘要:

脑胶质瘤是中枢神经系统最常见的原发性肿瘤,由于缺乏针对性的靶向药物,肿瘤化疗效果不佳。阿霉素是在临床应用广泛的化疗药之一,按照阿霉素脂质体不同的表面修饰进行分类,介绍了阿霉素脂质体在脑胶质瘤靶向治疗中的应用,目前这类应用多是在基础研究中,也有部分临床实验中应用了阿霉素脂质体。本文主要阐述阿霉素脂质体的表面修饰及其在脑胶质瘤治疗研究中的应用。

关键词:

Abstract:

Glioma is the most common primary tumor of the central nervous system. Due to the lack of targeted drugs,tumor chemotherapy is ineffective. Doxorubicin is one of the widely used chemotherapeutic drugs in clinical practice. According to different surface modifications of doxorubicin liposomes,the application of doxorubi⁃ cin liposomes in the targeted therapy of brain glioma is introduced. Most of the doxorubicin liposomes are used in basic research,and some in clinical trials. Therefore,this paper mainly describes the surface modification of doxo⁃ rubicin liposome and its application in the treatment of glioma.

Key words:

glioma, doxorubicin, liposome